Bioinformatic analysis of genes and polymorphisms involved in ageing and development

Abstract

The aim of the study was to perform a bioinformatic analysis of gene’s polymorphisms, associated with ageing and age-associated diseases.

Materials and methods. Analysis of genes was performed with the use of information, obtained from the database of genome-wide association studies GWAS Catalog. String-DB database (v. 12.0) was used for analysis of protein-protein interactions (PPI).

Results. 7676 unique genes have been identified, the polymorphisms of which are associated with the development of age-associated diseases. The association of molecular functions of a number of genes (HLA-DQB1, HLA-DQA1, HLA-DRB1, FTO, APOE, APOC1 and MAPT) and their protein products with aging and age-associated diseases has been revealed.