Dynamics of motor activity and metabolic indices in rats on the model of pain syndrome in the maxillofacial region

Abstract

The aim: study of changes in locomotor activity, as well as eating and drinking behavior of female rats on a model of pain in osteoarthritis of the temporomandibular joint.

Material and methods. The studies were performed on 18 female Wistar rats. The animals were injected with sodium monoiodacetate in the temporomandibular joint. An automated Phenomaster unit (TSE Systems GmbH, Germany) was used to assess daily indices of the rats' motor activity, water and food intake.

Results. In the dynamics of observation it was found that body weight decreased in rats with pain syndrome, but increased in control animals. By the end of the experiment, individuals with induced pain were characterized by a decrease in feed and water consumption, as well as a decrease in daily motor activity.

Conclusion. The development of pain syndrome in the maxillofacial region leads to suppression of locomotor activity, suppression of eating and drinking behavior.