Comprehensive assessment of the impact of synuclein proteins on motor function in age-related changes

Authors

  • O. A. Morozova Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences, Chernogolovka of Moscow Region, Russian Federation; I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation http://orcid.org/0009-0005-0538-4087
  • A. M. Krayushkina Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences, Chernogolovka of Moscow Region, Russian Federation http://orcid.org/0000-0002-6830-3820
  • Yu. S. Sukhanova Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences, Chernogolovka of Moscow Region, Russian Federation http://orcid.org/0000-0002-1867-6813
  • T. A. Ivanova Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences, Chernogolovka of Moscow Region, Russian Federation
  • K. D. Chaprov Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences, Chernogolovka of Moscow Region, Russian Federation http://orcid.org/0000-0002-0258-1879

DOI:

https://doi.org/10.25557/2310-0435.2024.02.67-71

Keywords:

alpha-synuclein, beta-synuclein, gamma-synuclein, synucleins, motor dysfunction, gait analysis, neurodegenerative diseases

Abstract

Actuality. Dopamine neurotransmission impairment is a common phenomenon in neurodegenerative diseases associated with motor dysfunction. The involvement of synuclein proteins in the regulation of dopamine homeostasis renders their study pertinent in the context of pathology.

The aim of this study is to identify the impact of different combinations on motor function developed with ageing, in knockouts of synuclein family genes.

Materials and methods. Eight groups of animals were tested in the CatWalk XT automated system, and their muscle strength was evaluated using the Grip Strength Test Meter at 6, 12, 18 and 24 months of age. Statistical analysis was carried out using GraphPad Prism Software 7.0.

Results. A significant reduction in the ‘print length’ parameter with age was observed in the groups of animals lacking functional alpha-synuclein. Furthermore, other gait abnormalities were observed in these animals. Our study indicates that the absence of beta- and gamma-synuclein is associated with a significant reduction in body weight and impaired grip strength.

Conclusion. The present study has demonstrated the pivotal role of synuclein family proteins in the impairment of motor function in animals with age. Furthermore, it has identified several hidden parameters that introduce changes in the gait of animals with different combinations of synuclein genes knockouts.

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Published

2024-07-16

Issue

Vol. 22 No. 2 (2024): Патогенез

Section

Brief reports

How to Cite

Comprehensive assessment of the impact of synuclein proteins on motor function in age-related changes. (2024). Patogenez (Pathogenesis), 22(2), 67-71. https://doi.org/10.25557/2310-0435.2024.02.67-71

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