Role of opioidergic and GABAergic systems in chemosensitivity control to carbon dioxide in rats

Abstract

In experiments on 25 anaesthetized rats the changes in the respiratory system chemosensitivity to hypercapnia were investigated under conditions of ц-opioid receptors agonist morphine and GABA-receptor agonist phenibut. Alter 30–45 min of systemic morphine or phenibut administration the respiratory system sensitivity to hypercapnia was changed significantly. Activation opioid receptors by morphine or GABA-receptors by phenibut in rats resulted in overturning of chemosensitive respiratory control circuits. These facts confirm important role of opioidergic and GABAergic systems in neurohymoral mechanisms of central respiratory control disturbances.