HDL-Therapy – Therapeutic approaches to correction of High-density lipoproteins dysfunction

Abstract

The authors describe in this review the promising therapeutic approaches for raising HDL levels in blood for inhibition of atheroscletosis. The mechanisms of action and efficacy of the most commonly used and emergtng drugs for this purpose are discussed. It is assumed that the development of new opportunities that stimulate formation of these lipoprotein fractions can reduce the severity of cardiovascutar pathology. There is a growing attention to the ability to characterize the functionality of HDL caused by their heterogeneity. These data suggest the most likely use of more than one therapeutic approach to successfully elevate the content of HDL.