Choline acetyltransferase and its role in regulation of an exchange and secretion of acetylcholine

Abstract

The review of modern concepts concerning forms of choline acetiltransferase (ChAT) and localization dependent factors of regulation of activity synaptic ChAT is presented. It is supported that the compartmentalization of enzyme delimits involvement of ChAT in different functional and metabolic cycles. Correlation of reaction at in vitro and in vivo experiments of soluble and membrane-bound ChAT is shown, and a variety of the functional effects on cholinergic synapses in vivo.