Research of angiogenic potential of human multipotent mesenchymal stromal cells

Authors

  • I. N. Saburina Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; Russian Medical Academy of Continuing Vocational Education, Moscow, Russian Federation
  • A. A. Gorkun Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • I. M. Zurina Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  • N. V. Kosheleva Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; M.V. Lomonosov Moscow State University, Moscow; Russian Federation
  • V. S. Repin Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; Russian Medical Academy of Continuing Vocational Education, Moscow, Russian Federation

Keywords:

multipotent mesenchymal stromal cells, angiogenesis, endothelial progenitor cells, Matrigel

Abstract

To study the angiogenic potential of cell cultures a new 3D model of using the VEGF-induced spheroids from umbilical cord multipotent mesenchymal stromal cells (UC MMSC) was elaborated. It was shown that in the process o f forming spheroids UC MMSC the number of early endothelial progenitor cells expressing CD34+, CD133+ increased as compared with 2D culture. The expression of markers of late endothelial progenitor cells (CD31+/vWF+/ F lk -1+/ VEGF+) was induced by VEGF. After transfer into Matrigel in spheroids the formation tubular like structures were discovered.

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Published

2023-05-26

Issue

Vol. 11 No. 1 (2013): Патогенез

Section

Original investigations

How to Cite

Research of angiogenic potential of human multipotent mesenchymal stromal cells. (2023). Patogenez (Pathogenesis), 11(1), 59-62. https://test.pathogenesis.pro/index.php/pathogenesis/article/view/685

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