The search direction means for reducing endotoxin concentration in the general haemocirculation

Abstract

Introduction. Endotoxin (ET) is a lipopolysaccharide (LPS), which is a mandatorycomponentofthe membrane of Gram-negative bacteria of the intestinal microflora and has high biological activity. Excessive concentration of ET in the systemic circulation, dubbed «endotoxin aggression», induces systemic inflammation and is a universal factor in the pathogenesis of diseases and syndromes. Aims. We conducted a search of medicines and medical treatments that can reduce the content of ET in general haemocirculation. Methods. We used the generally accepted clinical and serological methods of research, as well as the LAL test in the author’s modification adapted to the clinical setting, the results of which were processed statistically using Student’s t test. Results. Combined therapy of giardiasis 2.5 times reduced the content of LPS in the bloodstream of patients, but did not lead to a decrease in average concentration of ET to the normative values. Immunomodulator caused a slight decrease in the concentration of LPS in the blood in 14 volunteers with persistent viral infection. Sorbents reduced the concentration of ET in the bloodstream in 20 (64.5%) of volunteers. Biotics reduced the concentration of LPS in haemocirculation in 4 volunteers from 11 (36.4%). The use of a diuretic found no significant differences in the averages concentration of ET, but in 4 volunteers (23.5%) occurred the reduction of LPS in the general circulation. Sadenosylmethionine caused decrease of LPS in serum of 11 volunteers (52%).