Simulated microgravity in biomedicine

Abstract

Biotechnological research in space has led to significant scientific breakthroughs and technological developments with a great applied potential in medicine, pharmacology and tissue engineering. Microgravity research is an important part of space biology and human physiology. Ground-based modeling of simulated microgravity using different cell and tissue cultures is aimed at preparing future space missions. Simulated microgravity allows exploring molecular and cellular mechanisms of biological effects on cell stress and transformations of normal and tumor cells under changed gravity. Cell biology research in space provided a better understanding of cell and body physiology. This review presents information of recent years about cell changes in microgravity and discusses the prospects for using simulated microgravity in space biotechnology.