Immune and antioxidant disorders in Parkinson's disease

Abstract

Parkinson disease (PD) is characterized by progressive loss and damage of nigral dopaminergic neurons resulting in the reduction of dopamine level in the striatum. The most important factors leading to dopaminergic neurons loss are oxidative stress, mitochondrial dysfunction, activation of NMDA-receptors etc. Abnormalities of neural, immune, and endocrine systems regulation establish risk and provide the disease progress. Materials and methods. Clinical parameters (according to UPDRS), immune, hormonal and antioxidant status was dynamically determined in PD patients with interval of 3 month during standard antiparkinson therapy. Results. The results show the disfunctions of parameters studied. Conclusion. Data obtained may indicate that immune, hormonal and antioxidant disorders are associated with the pathogenesis of this slowly progressive, multifactorial neurodegerative disease.