Effect of release-active antibodies on the in vitro functional activity of H4-receptors

Authors

  • P. L. Naplyokova LLC NPF Materia Medica Holding, Moscow, Russia
  • A. G. Emelyanova Institute of General Pathology and Pathophysiology, Moscow, Russia
  • S. A. Tarasov Institute of General Pathology and Pathophysiology, Moscow, Russia
  • E. N. Kozhevnikova Institute of General Pathology and Pathophysiology, Moscow, Russia
  • S. G. Morozov Institute of General Pathology and Pathophysiology, Moscow, Russia

DOI:

https://doi.org/10.25557/2310-0435.2018.03.135-137

Keywords:

histamine, released-active antibodies, allergy, H4-receptor, GTPγS assay

Abstract

The aim of the study was to evaluate the effect of released-active antibodies (RA Abs) to histamine on the functional state of H4-receptor using the GTPγS assay in vitro. Experiments were performed on CHO-K1 cell membranes expressing the human recombinant H4-receptor. The functional activity of H4-receptor was assessed by the amount of GTPγ[35S] bound to the membranes. It was shown that RA Abs to histamine were antagonistic to H4-receptors.

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Published

2018-12-31

Issue

Vol. 16 No. 3 (2018): Pathogenesis

Section

Brief reports

How to Cite

Effect of release-active antibodies on the in vitro functional activity of H4-receptors. (2018). Patogenez (Pathogenesis), 16(3), 135-137. https://doi.org/10.25557/2310-0435.2018.03.135-137

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