Neuroprotection on experimental ischemic insult of prefrontal areas of the brain cortex

Abstract

It was shown neuroprotective and antiamnestic action of GK-2H with comparison to peptides noopept and semax on model bilateral focal ischemical intury of prefrontal areas of the rat brain cortex. It is stated that intraperitoneal injection of GK-2H in dose 0,1 mg/kg on 1 or 4 hours and further on 2-nd, 4-th and 8-th days after operation leads to decrease of volume of cortical infarction to 47% or 65% and restoration of reproduction of passive avoidance reflex aquired before experimental ischemic insult on 42% and 60% accordingly. It was concluded that GK-2H possesses neuroprotective properties.